CTU Bern

STREAM started enrollment

31.01.2022 – STREAM is a multicenter, randomized, non-inferiority trial conducted in multiple hospitals in Switzerland. The trial investigates the effects of discontinuing statin therapy compared to continuing statin therapy in multimorbid elderly adults without clinical cardiovascular disease (CVD).

Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of CVD in middle-aged subjects, their benefits for primary prevention in older people (aged ≥70) without CVD are uncertain, particularly for those with multimorbidity. However, statin side effects and drug interactions are common in a multimorbid elderly population and can negatively impact quality of life and increase adverse drug reaction-related hospitalizations. The aim of STREAM is to conduct a statin deprescribing randomized controlled trial (RCT) to provide guidance on the long-term benefits and risks for the ever-growing multimorbid elderly population.

The trial is funded by the Swiss National Science Foundation (SNF) and is planned to enrol 1800 participants over 4 years. The first trial participant was enrolled at the Inselspital Bern in November 2021.

CTU Bern is highly involved in this trial with the following divisions: Clinical Study Management, Statistics & Methodology, Data Management, and Monitoring. Further Information can be found under www.statin-stream.ch.