CTU Bern

Project Database

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CTU Project No.NameStart yearOne-Sentence SummaryInvolved divisionsSponsorFundingClinicalTrials.gov Identifier
FertiTOX2023lmpact of gonadotoxic therapies on fertility.Data Management Light service, StatisticsProf, Dr. med. Michael von WolffKrebsligaNCT05885048
OPERAM Long-Term cohort2022Preventive care in type 2 diabetes: improving risk prediction among older and multimorbid adultsData Management Full ServiceProf. Dr. med. Nicolas RodondiSNF
TakedaTTP2022Export and preparation of the thrombotic thrombocytopenic purpura registry data for meta-analysis.StatisticsProf. Dr. med. Johanna Kremer HovingaTakeda Pharmaceutical Company Limited
Burden of Sleep wake disorders2022EAN – The Burden of Sleep/Wake disorders: Excessive daytime sleepiness and insomnia project – Work Package II - Pilot study.Document Development, Data Management Full ServiceProf. Dr. med. Claudio BassettiEuropean Academy of Neurology (EAN)
EMBARC2022An investigation of local and systemic immune function in patients with bronchiectasis.StatisticsDr. Moritz SaxenhoferCSL Behring AG
TOGETHER2022Structured shared decision making vs. usual care for patients undergoing elective surgical or transcatheter aortic valve replacement (TOGETHER): A randomized-controlled trial.Data Management Light Service, Statistics, Central Data MonitoringProf. Dr. med. Thomas PilgrimUniversitätsklinik für Kardiologie, Inselspital Bern
REDE-AF2023A single-arm clinical investigation to assess whether renal denervation can reduce arrhythmia burden in patients with recurrent paroxysmal atrial fibrillation despite durable pulmonary vein isolation.Data Management Light Service, Statistics, On-site MonitoringProf. Dr. med. Laurent RotenMedtronic, University Hospital/InselspitalNCT05817318
TITAN-DEB2022TicIn for the Treatment of long coronAry lesioNs with Drug Eluting Balloons.Data Management Light Service, StatisticsProf. Dr. med. Marco Valgimiglin/a
B-Free2023Booster-free antiretroviral therapy for persons living with HIV and multidrug resistance: A multi-stage randomized trial.Document Development, regulatory Support, Clinical Study Management, Data Management Full Service, Study Website Development, Statistics, Central Data Monitoring, On-site MonitoringProf. Dr. med. Gilles WandelerSNCFNCT06037564
TreoMel2022Prospective comparison of treosulfan with melphalan versus melphalan alone for high-dose chemotherapy before autologous transplantation in multiple myeloma patients.Data Management Full Service, On-site MonitoringProf. Dr. med. Thomas PabstUniversity Hospital/Inselspital
SMASH2022Simplified meal approach study using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes – a randomised controlled two-centre crossover trial.Data Management Light Service, On-site MonitoringProf. Dr. med. Lia Ballyn/aNCT05481034
DMT-HAR-TOM2022Aliveness and Psychedelics: A neuropsychopharmacological approach to modulate Theory of Mind in healthy subjects under the influence of pharmahuasca.On-site MonitoringReconnect Labs AGReconnect Labs AG
INTOMOB2022Effects of an INntervention TO increase MOBility in older hospitalized medical patients (INTOMOB): a cluster randomized controlled trialDocument Development, Data Management Light Service, Statistics, On-site MonitoringDr. med. Carole Elodie AubertSNF
SONOBIRDIE Trial2022SONOlysis in prevention of Brain InfaRctions During Internal carotid Endarterectomy.StatisticsProf. David Školoudíkn/aNCT02398734
Single Shot Champion2022Interventional study with investigational medical device (MD): The SINGLE SHOT CHAMPION TrialData Management Light Service, Statistics, On-site MonitoringProf. Dr. med. Tobias ReichlinResearch Funds of the Department of Cardiology, Inselspital Bern and University Hospital Basel
BELEAVE2022The Bern Leadless AV versus DDD pacing study: A randomized controlled single-center trial on leadless versus conventional cardiac dual-chamber pacing.Data Management Light Service, Statistics, Central Data Monitoring, On-site MonitoringPD Dr. med. Dr. phil. Andreas HaeberlinDepartment of Cardiology, Inselspital Bern
Cannabispilotversuch Biel2022Cannabispilotversuch Stadt Biel gemäss der Verordnung über Pilotversuche nach dem Betäubungsmittelgesetz BetmPVData Management Light Service, on-site MonitoringFlorian WehrliAd5 GmbH
BEready2022Multidisciplinary Center for Infectious Diseases core activity proposal: BEready cohort.Data Management Full Service, Statistics, Clinical Study ManagementProf. Dr. med. Nicola Low
Umbrella Registry: Zirconia Dental Implants2022Post Market Clinical Follow up (PMCF) medical device registry of Z-Systems Zirconia Dental Products: Z-Systems RegistryData Management Full ServiceZ-Systems AGZ-Systems AG
FENDER2022Fecal Microbiota Transplantation Versus Vancomycin or Fidaxomicin in Clostridioides difficile Infection First Recurrence: A Randomized, Controlled, Open-label, Multicenter Phase III Clinical TrialDocument Development, On-site MonitoringCentre hospitalier universitaire Vaudois (CHUV)SNFNCT05266807
DeIntensiFpilot2022Multicenter randomized trial comparing an individualized de-intensified and conventional follow-up strategy after curative treatment in head and neck cancer.Document Development, Regulatory Support, Clinical Study Management, Data Management Full Service, Statistics, On-site MonitoringProf. Dr. med. Roland GigerSwiss Cancer Research
COVID-19 Lung Cohort Study2022Prospective Observational Cohort Study to Investigate Long-term Pulmonary and Extrapulmonary Effects of COVID-19.StatisticsProf. Thomas K. GeiserLungenliga Bern
A34RCT2022Outcome of Surgical versus Primary Non-Surgical Treatment of Traumatic Thoracolumbar Spine Burst Fracture in Patients without Neurological Symptoms: A Randomized Controlled Clinical Trial. Document Development, Regulatory Support, Data Management Full Service, Statistics, On-site MonitoringPD Dr. med. Christoph E. AlbersSchweizerische Akademie der Medizinischen Wissenschaften, Swiss Orthopaedics, Ortho Team Bern, SUVA
SCRIPT-22022The Safer Cannabis – Research In Pharmacies randomized controlled Trial 2 (SCRIPT-2)Clinical Study ManagementProf. Dr. med. Reto Auer
StOP-22022STOP? II trial: Cluster randomized clinical trial to test the implementation of a toolbox for structured communication in the operating room.Regulatory Support, Data Management Full Service, Study Website, Statistics, Central Data Monitoring, On-site MonitoringProf. Dr. Guido BeldiSNF
HypoFocal-SRT2022A single arm phase II trial for hypofractionated focal salvage radiotherapy for isolated prostate bed recurrence after radical prostatectomy.Data Management Full Service, Statistics, Central Data Monitoring, On-site MonitoringDr. med. Mohamed ShelanDebiopharm AG
Thalamic Burst-DBS for neuropathic pain2022Burst-Deep Brain Stimulation of the thalamus for Neuropathic Facial Pain and Central Poststroke Pain: a prospective, randomized cross-over feasibility trial.Document Development, Data Management Light Service, Statistics, On-site MonitoringDr. med. Andreas NowackiNCT05204472
SURPRISE2022SURPRISE+: SURveillance of infectious diseases among health PRofessionals In SwitzErland – a longitudinal, multicentre open cohortData Management Full ServicePD Dr. med. Philipp KohlerSNF, Federal Office of Public Health, Health Department of the Kanton St. Gallen
TECNO2022Safety and Efficacy of intra-arterial Tenecteplase for non-complete reperfusion of intracranial occlusions.Document Development, Regulatory Support, Study Website, Data Management Full Service, Statistics, Central Data Monitoring, on-site MonitoringProf. Dr. med. Urs FischerSNF
PREHABIL Trial2022Multimodal prehabilitation for major surgery in elderly patients to lower complications: A randomised, prospective, multi-centre, multidisciplinary trial (PREHABIL Trial).Data Management Light Service, Statistics, On-site MonitoringDr. med. Dominique EngelSNF, Department of Anaesthesiology and Pain Medicine on the University Hospital Inselspital BernNCT04461301
GAIN-INST-Trial2022Guidance of adjuvant instillation in intermediate risk non-muscle invasive bladder cancer by drug screens in patient derived organoids. A Single center, Open-label, Phase II trial with a feasibility endpoint.Proctocol Development, Data Management Full Service, Statistics, On-site MonitoringProf. Roland Seiler-BlarerSpitalzentrum BielNCT05024734
MINOCA2022An observational single-arm multicenter study to detect atrial fibrillation in MINOCA patients with an implantable cardiac monitor.Data Management Light Service, on-site MonitoringProf. Dr. med. Lorenz RäberBangerter-Rhyner Stiftung (Basel, Switzerland)
StibTax2021Subcutaneous Stibium metallicum praeparatum 6x versus placebo in the prevention of paclitaxel- or nab-paclitaxel-induced peripheral neuropathy: the StibTax double blind randomized controlled trial.Document Development, Regulatory Support, Data Management Light Service, Statistics, On-site MonitoringProf. Dr. med. Ursula Wolfn/aNCT04715542
LUSPLUS2022A phase IIIb, open-label, single arm study to evaluate the efficacy and safety of luspatercept in patients with lower-risk MDS and ring-sideroblastic phenotype (MDS-RS).Clinical Study Management, On-site MonitoringGWT-TUD GmbH, Dresden, Germanyn/a
KIC-START2021A Low-Interventional Study To Evaluate Clinical, Biochemical, And Patient-Reported Responses To Tofacitinib Induction Therapy For Ulcerative ColitisData Management Full Service, StatisticsPfizerPfizerNCT05069259
RetroperitonealSarcoma2021The Use of systemic therapy in Retroperitoneal Sarcoma.Data Management Full Service StatisticsPD Dr. med. Attila KollàrUniversitätsklinik für Medizinische Onkologie Bern
SOS Peritonitis2021The Effect of Intraoperative Peritoneal Lavage with Super-Oxidized Solution on Surgical Site Infections and Mortality in Patients with Secondary Peritonitis: A Randomized Controlled Trial.Data Management Light Service, On-site MonitoringDr. med. Tobias HaltmeierMedical Systems Solution GmbHNCT05050253
Paracetamol for cancer pain control2021Effect of paracetamol in addition to WHO Step III opioids in chronic cancer pain control - a randomized, double-blind, placebo-controlled parallel group study.Data Management Full Service, Statistics, Central Data Monitoring, On-site MonitoringPD Dr. med. Evangelia LiakoniSNFNCT05088876
Magrolimab2021To investigate the safety of combining the antibody magrolimag with standard first line platinum-based chemotherapy (with cisplatin /gemcitabine) in advanced urothelial carcinoma.Data Management Full Service, Document Development, Regulatory Support, Statistics, On-site MonitoringPD. Dr. med. Bernhard KissSNF
Co-STAR2021Colchicine for patients with aortic stenosis undergoing transcatheter aortic valve replacement (Co-STAR): a randomized-controlled trial.On-site MonitoringProf. Dr. med. Thomas PilgrimUniversitätsklinik für Kardiologie, Inselspital BernNCT04870424
HeMoVal2021Hemoglobin in the cerebrospinal fluid to monitor for secondary brain injury after aneurysmal subarachnoid hemorrhage - a prospective multinational validation study.Data Management Full Service, Document Development, Regulatory Support, Clinical Study Management, Central Data Monitoring, On-site MonitoringProf. Dr. med. Dominik SchaerCSL Behring AGNCT04998370
Bazedoxifene2021Single-center, prospective, non-randomized trial, to investigate Bazedoxifene as a concomitant treatment for patients with metastatic pancreatic adenocarcinoma - the BAZE-trial.Data Management Light Service, Statistics, On-site MonitoringDr. med. Lucie VignotHFR Grant
MDR-Ent2021Molecular Features of Multidrug-Resistant Enterobacterales Colonizing Swiss Embassy Employees and Their Relatives.Data Management Full Service, StatisticsProf. Dr. med. Andrea EndimianiSNF
NEON2021Safety evaluation of intravenous Talineuren (TLN) in Parkinson's disease-affected patients.Data Management Full Service, Regulatory Support, Clinical InvestigationInnoMedicaInnoMedica Switzerland AGNCT04976127
SilexanNMA2021Comparative efficacy and acceptability of Silexan versus synthetic anxiolytic drugs for the treatment of anxiety disorders: A systematic review and network meta-analysis.StatisticsH+O communications Ltd.n/a
Goal-directed mobilization2021Goal-directed Mobilization of Medical Inpatients (GoMob-in) - a randomized, controlled trial.Data Management Light Service, Statistics, On-site MonitoringDr. med. Fabian LiechtiSGAIM Foundation, Bern, SwitzerlandNCT04760392
RadiotracerPC2021Head-to-head comparison of Ga-PSMA-11 and F-PSMA-1007 for the detection of recurrent prostate cancer in PSMA-ligand PET/CT and determination of optical imaging timing.Data Management Light Service, Statistics, On-site MonitoringProf. Dr. med. Axel RomingerBerger-Janser Stiftung zur Krebserforschung & bernische Krebsliga
STREAM-752021Discontinuing Statins in Multimorbid Older Adults without Cardiovascular Disease - a Randomized Non-Inferiority Clinical Trial.Data Management Full Service, Study Website, Statistics, Clinical Study Management, On-site Monitoring, Central Data MonitoringProf. Dr. med. Nicolas RodondiSNFNCT05178420
DIFU2021Immediate revascularization versus standard of care alone in patients with diabetic foot ulcer and non-critical peripheral artery disease: a randomized, controlled trial.Document Development, Data Management Full Service, Study Website, Statistics, Clinical Study Management, On-site Monitoring, Central Data MonitoringProf. Dr. med. Iris BaumgartnerSNFNCT04939038
RET2022Sensory recovery of digital nerves after primary repair using microsurgical epineural end-to-end neurorrhaphy alone, or in combination with Tisseel® fibrin sealant enwrapping - RET.Document Development, On-site Monitoring, Data Management Full Service, StatisticsProf. Dr. med. Esther VögelinJohanna Bol Foundation, Baxter Company
Tuberculini2020Development of novel diagnostic test to provide personalized antibiotic therapy regimen for tuberculosis patients.Data Management Full Service, StatisticsDr. med. Peter KellerInnosuisse
SEPAIS2020Secondary Prevention and Outcome after Acute Ischemic Stroke (AIS).Data Management Full ServiceProf. Dr. med. Marcel ArnoldInsel Gruppe AG, Universitätsklinik für Neurologie
PASTA Trial2021High Dose Steroids in Children with Stroke and Unilateral Focal Arteriopathy: A Multicentre Randomized Controlled TrialDocument Development, Regulatory Suport, Data Management Full Service, Study Website, Statistics, On-site Monitoring, Central Data MonitoringProf. Dr. med. Maja SteinlinSNFNCT04873583
POLICOV2020Police officer COVID-19 Seroprevalence Survey in the Canton of Bern, Switzerland.Data Management Full Service, StatisticsProf. Dr. med. Parham SendiPolice Department Canton Bern, Ifik Bern, Interregionale Blutspende SRK BernNCT04643444
COMPARE CRYO2020Comparison of the PolarX and the Arctic Front Cryoballoon for Pulmonary Vein Isolation in Patients with Symptomatic Paroxysmal Atrial Fibrillation - A Multi-Center Non-Inferiority Design Clinical Trial.Data Mangement Light Service, Statistics, On-site Monitoring,Prof. Dr. med. Tobias ReichlinDepartment of Cardiology Inselspital Bern and University Hospital BaselNCT05095909
Solidarity Vaccine Trial2020An international randomised trial of candidate vaccines against COVID-19.Statistical Analysis, Reporting, Central Data MonitoringWorld Health OrganizationWorld Health Organization
COVID-19 in acute cardio2020Effects of SARS-CoV-2 infection on outcomes in patients hospitalized for acute cardiac conditions. A prospective, multicenter cohort study.StatisticsProf. Stephan WindeckerInsel Gruppe AG, Universitätsklinik für Kardiologie
SEECS2020Swiss Eosinophilic Esophagitis Cohort StudyData Management Full Service, StatisticsProf. Dr. med. Alain SchöpferSNF
PRAETOR-ML2020Development and external validation of an international, multicenter machine learning algorithm or prediction of adverse events after lung resection. The Prediction of Adverse Events after Thoracic Surgery by Machine Learning (PRAETOR-ML) StudyData ManagementProf. Ralph SchmidUniversitätsklinik für Thoraxchirurgie
SWEETSTONE2020Randomized, double-blind, placebo-controlled crossover trial assessing the impact of the SGLT2 inhibitor empagliflozin on urinary supersaturations in kidney stone formers.Document Development, Data Management Full Service, Statistics, On-site MonitoringProf. Dr. med. Daniel FusterBoehringer Ingelheim, Basel, SwitzerlandNCT04911660
ROSE2020Correctness of diagnosing eye disease using an objective, quantitative and semi-automatic eye examination - ROSE.Data Management Light Service, StatisticsProf. Dr. med. Mathias AbeggHans Goldmann Stiftung
Swiss Health Study2020Epidemiological study / pilot study for prospective cohort study. The Swiss Health Study - pilot phase is the pilot study for a 100 000+ cohort study, in which procedures and infrastructures for recruitment, participation, data and sample management will be set up and tested.Clinical InvestigationFederal Office of Public Health (FOPH)FOPH, Unisanté and in kind contribution of the Swiss Biobanking Platform (SBP)
MPN-Gas62020Investigation of the in vivo role of Gas6/Axl pathway in Philadelphia-negative myeloproliferative neoplasms - Translational Study.Data Management Full Service, StatisticsPD Dr. med. Alicia RovóSNF (Swiss National Foundation)
Ebola Safety Reporting2020Compassionate healthcare and frontline workers and ring vaccination project intended to evaluate safety of the Ebola vaccine.Central Data MonitoringNational Ministry of HealthWorld Health Organization (WHO)
Thrombophilie HZLA Register2020Retrospective analysis of hereditary and acquired risk factors, clinical presentation and treatment of patients with arterial and venous thromboembolic events and pregnancy morbidity.Data Management Full Service, StatisticsProf. Dr. med. Anne Angelillo-ScherrerUniversity Hospital Bern (Inselspital)
SOLIDARITY TRIAL2020An international randomised trail of additional treatments for COVID-19 in hospitalised patients who are all receiving the local standard of careStudy Website, Statistics, On-site Monitoring, Central Data MonitoringNational Ministry of Health and the World Health OrganisationWorld Health Organization (WHO)NCT04647669
SAM2020The South African Cancer Match Study: South African HIV cohort with cancer outcomes based on routine laboratory dataStatisticsPD Dr. med. Julia BohliusSNF
PHARAO2020PHysiology in Anaesthesia Regarding Apnoeic Oxygenation during nasal cannula therapy at different flow rates. Comparing high flow, medium flow and low flow nasal cannula therapy. A single-centre prospective randomized controlled trialStatisticsProf. Dr. med. Robert GreifDepartmental Anaesthesia Research FundNCT01366703
Fibrotic NAFLD in diabetes2020FINADIA: Non-Invasive Findings of Fibrotic NAFLD Patients in DIAbetology Outpatient ClinicData Management Full Service, StatisticsProf. Dr. med. Jean-François DufourGilead
AB-PSP-0012020A multicenter, device clinical study for the early diagnostic os sepsis and potential impact on antibiotic management based on serial Pancreatic Stone Protein (PSP) measured using the abioSCOPE in critically ill patients at high risk of sepsisStatisticsABIONIC SAABIONIC SANCT03474809
SARSCoV-2 and liver transplant2020Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection: epidemiology of an international liver transplant cohortData Management Full ServiceProf. Dr. Jean-François Dufourn/a
CORON-ACT2020A multicenter, double-blind, randomized, controlled phase II trial on the efficacy and safety of tocilizumab in the treatment of coronavirus induced disease (COVID-19)Data Management Full Service, Central Data Monitoring, Regulatory Support, Project Management, Statistics, Document DevelopmentProf. Dr. med. Peter M. VilligerUniversity Hospital Bern (Inselspital) and Roche Pharma (Schweiz) AGNCT04335071
NIBED2020A randomized, controlled cross-over first-in-man safety and efficacy trial of a novel non-invasive bladder emptying deviceDocument Development, Statistics, On-site Monitoring , Regulatory SupportProf. Dr. Fiona BurkhardInnosuisse GrantNCT04919798
Laser treatment in vulvar Lichen sclerosus2020Effect of Treatment with the ablative fractional carbodioxide laser in vulvar Lichen sclerosusData Management Full Service, On-site MonitoringProf. Dr. med. Michael D. MuellerUniversity Hospital Bern (Inselspital)NCT04134494
HEADWIND II2020A non-randomised, controlled, interventional single-centre study for the design and evaluation of an in-vehicle hypoglycaemia warning system in diabetesData Management Light Service, On-site MonitoringProf. Dr. med. Christoph StettlerSNFNCT04569630
HNO support2020Randomised, double-blind, multi-centre, clinical trial to assess the safety and efficacy of SDX-3101, an innovative vibration therapy portable device for the treatment of chronic rhinosinusitis without nasal polyps (CRSsNP) in adult patientsClinical InvestigationDr. med. Lukas AnschützSynDermix AG
VTE RAM Immobilization2020Risk stratification for hospital-acquired venous thromboembolism in medical patients: a prospective cohort studyData Management Light Service, StatisticsProf. Dr. med. Iris BaumgartnerGottfried und Julia Bangerter-Rhyner Stiftung, Novartis Foundation for medical-biological Research
Tissue graft versus collagen matrix in the treatment of gingival recessions2020A comparative assessment of connective tissue graft vs. a new collagen matrix for periodontal tissue thickening and coverage of single or multiple adjacent gingival recessions in the mandible of orthodontically treated patients: a single center randomized clinical trialMonitoringProf. Anton SculeanUniversität Bern Zahnmedizinische Kliniken
Nicotine PKPD2019Randomized crossover study comparing the pharmacokinetics and pharmacodynamics of two differet nicotine salt concentration vape system pods and an electronic cigarette using free-base nicotineData Management, Monitoring, Clinical InvestigationDr. med. Evangelia LiakoniUniversitätsklinik für Allgemeine Innere Medizin
ACT for Insomnia2020Acceptance and Commitment Therapy as a new treatment for adults with insomnia disorderData Management, On-site MonitoringDr. phil. Elisabeth Hertenstein, Prof. Dr. Christoph Nissen, UPDVelux Stiftung
RCT smoking cessation nicotine salt high low concentration2020Comparison of abstinence rates and non-nicotine toxicants exposure when using two different nicotine salt concentration vape system pods as smoking cessation toolData Management, Statistics, Central Data Monitoring, MonitoringDr. med. Evangelia LiakoniSNF
S Napoli2019Survey on Salmonella NapoliData ManagementBundesamt für Gesundheit BAGBAG
TERIS2020The TERIS Study: multi-center, randomized, double-blinded study of Teriflunomide® in radiologically isolated syndrome (RIS)Document Development Regulatory Support, Project Management, On-site MonitoringECRINCHU de Nice
ESG2019Effects of Endoscopic sleeve gastroplasty on hormonal markers of glucose-homeostasisData ManagementPD Dr. med. Markus LaimerScherbarth StiftungNCT04820036
VitCTrial2019Can Vitamin C reduce the risk of postoperative shoulder stiffness? A mono-center, double-blinded, randomized and placebo-controlled studyDocument Development, Regulatory Support, Data Management, MonitoringJanine AntonovCampus SLB Sonnenhof AG
SAFE SSPE2019Clinical Surveillance vs. Anticoagulation for low-risk Patients with Isolated Subsegmental Pulmonary Embolism: A Multicenter Randomized Placebo-Controlled Non-Inferiority TrialData Management, Statistics, Monitoring, Central Data MonitoringProf. Dr. med. Drahomir AujeskySNFNCT04263038
DapaStudy2019SGLT-2 inhibition using Dapagliflozin during and after physical exercise - Effects on glycemic variability, hormonal regulators of glucose homeostasis and ketone body in type 1 diabetes - a randomized, placebo-controlled, open-label, cross-over intervention studyData Management, MonitoringProf. Dr. med. Markus LaimerSNF
SM-FES2019Self-modulated functional electrical stimulation in Chronic Stroke Patients with Severe and Moderate Upper Limb Paresis: A Multi-Centre, Single-Blind, Randomized Parallel StudyData Management, Statistics, MonitoringProf. Dr. Mauricio ReyesInnosuisse Intento SANCT04014270
VANCO2019Suprafascial vancomycin powder for prevention of surgical site infections after instrumented posterior spinal fusion: A randomized controlled trailData Management, MonitoringDr. med. Christian UlrichGottfried and Julia Bangerter & Rhyner Stiftung
Ebola Meuri2019To support the R&D Blueprint Team to set-up, maintain and archive a Clinical Data Management Systemdatabase on individual Ebola virus disease patientsData Management, StatisticsWorld Health Organization (WHO)World Health Organization (WHO)
HDMM2019HDM201 and midostaurin (HDMM) in relapsed/refractory AML with FLT3mut and TP53wt and in newly diagnosed AML with FLT3mut and TP53wt not fit for intensive chemotherapy; a phase I studyData Management, MonitoringProf. Dr. med. Thomas PabstNovartisNCT04496999
PedIndex2019Comparing intranasal dexmedetomidine with oral or rectal midazolam for procedural sedation in the pediatric emergency department: a monocenter, prospective, randomized, rater-blinded study at the Pediatric Emergency Department BernData Management, MonitoringDr. med. Julia HöffeStiftung BatzebärNCT03399838
EpiOs2019Early feasibility study on EpiOs (Epi means around, Os means bone) leadsData Management, MonitoringWyss Center for Bio and Neuro EngineeringWyss CenterNCT04796597
HemMa SCD2019A Prospective Cross-Sectional Observational Study to Identify and Characterize Hematological Markers and Predictors of Hemolysis Severity of Sickle Cell Disease in Patients with Type Hemoglobin SS and S/ß-thal and to evaluate differences compared to a control group without hemolysisDocument Development, Regulatory Support, Data Management, Statistics, MonitoringPD Dr. med. Alicia RovóCSL Behring AG
SRT Phase I2019Quantitative and qualitative evaluation of selective retina therapy (SRT) in combination with real-time optical coherence tomography (OCT) for laser dosimetryDocument Development, Regulatory Support, Data Management, Monitoring, Central Data MonitoringProf. Dr.-Ing. Dr. med. Sebastian WolfUniversitätsklinik für Augenheilkunde, Inselspital Bern
Proaktiv2019A cluster randomized controlled trial of palliative needs assessment and palliative care in general practiceData Management StatisticsProf. Dr. med. Steffen EychmüllerSNFNCT04673760
B&B VTablation2020Prospective Registry of Patients Undergoing Ventricular Arrhytmia Catheter Ablation at the University Hospitals Bern and BaselData Management (outsourced) Central Data MonitoringProf. Tobias ReichlinDepartment of Cardiology at University Hospital Bern
PSP Diagnosis of Sepsis2019Prognostic Value of Pancreatic Stone Protein in Adult Patient: Systemic Review and Metaanalysis (MetaPSP)StatisticsProf. Dr. med. Yok-Ai QueAbionicNCT03474809
PAPA ARTiS2019Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ´Minimally-Invasive Staged Segmental Artery Coil-Embolization`: A Randomized Controlled Multicentre TrialMonitoringProf. Dr. med. Jürg SchmidliGerman Research Foundation, European Union´s Horizon 2020NCT03434314
VoiceS2019Voice Quality after Transoral CO2-Laser Surgery versus Single Vocal Cord Irradiation for Unilateral Stage 0 & I Glottic Larynx Cancer - A Randomized Phase III TrialData Management, StatisticsDr. med. Olgun ElicinExternal grants of Universitätsklinik für Radio-Onkologie, Inselspital Bern
Bone Anchored Port2019Metaanalysis for the historical control of the Bone Anchored Port - a Novel Vascular Access for Hemodialysis TreatmentStatisticsThomas FreiDiavantis AGNCT02069860
GCA Registry2019An open-ended registry of patients with giant cell arteritisData Management, StatisticsProf. Dr. med. Peter M. VilligerNCT04049071
PPVRP2019The Influence of a Pre-Operative Preparatory Virtual Reality Program on the Self-Assessed Anxiety of Children Undergoing Elective Surgery A Randomized Controlled TrialData ManagementProf. Dr. med. Steffen BergerDepartment of Pediatric Surgery, Inselspital University HospitalNCT03957525
OPTICO LM2019Multimodality assessment of intermediate left main stenosis: Comparison of optical coherence tomography-derived minimal lumen area, invasive fractional flow reserve and FFRCTData Management, Statistics, MonitoringProf. Dr. Lorenz RäberAbbott, HeartflowNCT03820492
EMISI Trial2019Efficacy of Metamizole versus Ibuprofen and a Short Educational Intervention versus Standard Care for patient with Acute and Subacute Low Back Pain: A Randomized, Factorial TrialMethodology, Data Management, Monitoring, ReportingDr. med. Maria WertliSNFNCT04111315
Gynocular Studies2019Diagnostic test accuracy of a mobile colposcope (Gynocular™), HR-HPV testing, and VIA for detection of high-grade squamous intraepithelial lesions of the cervix in women living with HIVData Management, StatisticsPD Dr. med. Julia BohliusSwiss Cancer Research, National Institute of Allergy and Infectious Diseases of the National Institutes of Health, ESTHER Switzerland foundation
CONNECT2019A Randomized Comparison of Long-Term Vascular Healing between Biodegradable Polymer (BP) versus Durable Polymer (DP) Everolimus Eluting Stents in Acute ST-Elevation Myocardial InfarctionStatisticsProf. Dr. Lorenz RäberBoston ScientificNCT04229134
CARDSUP2019Clinical Outcomes in patients in need of a non-permanent mechanical cardiocirculatory support system: CARDSUP - A multicentric SWISS Circulatory Support Registry.Data Management Basic/Light Service, Statistics,Prof. Dr. med. Lukas Christoph Hunziker MunschUniversity Hospital of BerneNCT04117230
EUNN2019European Narcolepsy registry, aimed at supporting research and new initiatives to treat and improve quality of life for people affected by Narcolepsy.Data Mangement Central Data MonitoringProf. Claudio BassettiUniversitätsklinik für Neurologie, Inselspital Bern, European Narcolepsy Network (EU-NN)
ESTxENDS2018Efficacy, Safety and Toxicology of Electronic Nicotine Delivery Systems as an aid for smoking cessation: The ESTxENS multicentre randomized controlled trialData Mangement, Statistics, Monitoring, Central Data MonitoringProf. Dr. Reto AuerSNF Lungen Liga Bern Swiss Cancer League Tobacco Prevention Fund TPF
BISS2017A multi-center, randomized, 18-month, non-inferiority study to compare the efficacy of botulinum toxin versus conventional strabismus surgery in the treatment of secondary strabismus, in patients aged between 1 and 17 yearsData Management, Statistics, Monitoring, Project Management, Central Data MonitoringPD Dr. med. Mathias AbeggSNF
Target READ2019Transition cAre inteRvention tarGeted to high-risk patiEnts To Reduce rEADmission (TARGET-READ): A preliminary observational cohort studyData Management, Statistics, Central Data Monitoring, On-site Monitoring, Clinical InvestigationProf. Dr. med. Jacques DonzéSNF
SWIFTdirect2017Solitaire™ With the Intention For Thrombectomy Plus Intravenous t-PA Versus DIRECT Solitaire™ Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke (SWIFT DIRECT)Data Management, Central Data Monitoring, Monitoring, StatisticsProf. Dr. Urs FischerMedtronic Minneapolis, Minnesota, USA
Preference Sensitive Care2017Variations in preference-sensitive care and controversial medical procedures in SwitzerlandStatisticsDr. med. Maria WertliSNF
H-PACS2016Prophylactic mesh implantation in patients requiring emergency laparotomy for the prevention of incisional hernia: A randomized controlled trialData Management, Monitoring, StatisticProf. Dr. med. Guido BeldiLifecell
ELAN2017An international, multicenter randomized-controlled trial comparing early versus standard initiation of anticoagulation in patients with stroke and atrial fibrillationData Management, Central Data Monitoring, Monitoring, StatisticsProf. Dr. med. Urs FischerSNF
Simpl'HIV trial2017Evaluation of a simplified strategy for the long-term management of HIV infection: a non-inferiority, randomized, controlled, open-label clinical trialData Management, Monitoring, StatisticProf. Dr. med. Alexandra CalmySNF
DAWN2 CH2016Diabetes Attitudes Wishes and Needs (DAWN)2 Study in Switzerland: A survey study of psychosocial issues in diabetes and patient-centered diabetes careData ManagementPD Dr. med. Markus LaimerNovo Nordisk AG
EVOPACS2017Effect of PCSK9 inhibitor with EVOlocumab on early reduction of LDL-cholesterol levels in patients with Acute Coronary Syndromes (EVOPACS): a randomized, double-blind, placebo-controlled multicenter studyProject Management, Data Management, Central Data Monitoring, Monitoring, StatisticsProf. Dr. Stephan WindeckerAmgen Switzerland AG
NOSTONE2016A 3 year prospective, multicenter, double blind, placebo-controlled trial to assess the effectiveness of standard and low dose hydrochlorothiazide treatment in the recurrence prevention of calcium containing kidney stonesMethodology, Project Management, Data Management, Monitoring, Central Data Monitoring, StatisticsProf. Dr. med. Daniel FusterSNF
TAVI LAAC AFIB2017Combined Transcatheter Aortic Valve Implantation and Percutaneous Closure of the Left Atrial Appendage: an Investigator-Initiated TrialProject Management, Data Management, Statistics, Central Data Monitoring, On-site MonitoringProf. Dr. med. Lorenz Räber, Universitätsklinik für KardiologieBoston Scientifics
SERVE2017Effect of phosphodiesterase-5 inhibition with Tadalafil on SystEmic Right VEntricular function - a multi-center, double blind, randomized, placebo-controlled clinical trial - SERVE TrialMethodology, Data Management, Monitoring, Statistics, ReportingProf. Dr. Markus SchwerzmannSNF
MASTER DAPT2016Management of high bleeding risk patients post bioresorbable polymer STEnt implantation with an abbReviated versus prolonged DAPT regimen: an international, multicenter, randomized-controlled trialData Management, Monitoring, Statistic, ReportingEuropean Cardiovascular Research Institute (ECRI)Terumo Medical Corporation
SYMPTOM NAVI Pilot2016Implementation of the Symptom Navi© Program for cancer patients in ambulatory services: A cluster-randomized pilot studyData Management, Monitoring, StatisticDr. Manuela EicherStiftung Lindenhof Bern
SCRIPT2016A randomized-controlled trial evaluating the effects of regulated cannabis selling in pharmacies - The Safer Cannabis - Research In Pharmacies TrialProject Management, Data Management, StatisticsDr. med. Sven TrelleUniversity of Bern
SCOPE I2017A randomized controlled non-inferiority trial evaluating early safety and clinical efficacy of the Symetis ACURATE Neo compared to the Edwards Sapien 3 bioprosthesis in transcatheter aortic valve implantationData Management, Statistic, Monitoring, ReportingProf. Dr. Stephan WindeckerSymetis SA
REVEAL in TAVI2016Prospective research project investigating the incidence of arrhythmias in patients undergoing transcatheter aortic valve implantationData ManagementProf. Dr. med. Laurent RotenSNF Medtronic (Schweiz) AG
SAAL2015CD34+ selected versus unselected autologous stem cell transplantation in advanced stage mantle cell and diffuse large B-cell lymphoma patients, a randomized phase II study (the SAAL-trial)Data Management, Monitoring, StatisticsProf. Pabst ThomasMiltenyi Biotec GmbH
OPTICO BVS2016A randomized-controlled trial to compare optical-coherence-tomography- with angiography-guided percutaneous coronary intervention in patients with de-novo coronary artery disease undergoing coronary revascularizationMethodology, Project Management, Data Management, Monitoring, Statistics, ReportingDr. Räber LorenzSt. Jude Medical
Effect of anaesthetic techniques on clinical outcome after LSP, RA vs GA, a prospective RCT2016A randomized-controlled trial to evaluate the effect of general versus regional anesthesia on clinical outcomes in patients undergoing lumbar spine surgeryData Management, StatisticsMD Bänziger Bertram
OSCAR GALILEO2015A global multicenter, open-label, randomized, event-driven, active-controlled study comparing a rivaroxaban-based antithrombotic strategy to an antiplatelet-based strategy after transcatheter aortic valve replacement (TAVR) to optimize clinical outcomesMonitoringCardialysis BVBayer AG
Ebola vaccine trial2015Two trials of a new Ebola Virus vaccine: 1) ring-vaccination (cluster-) randomized-controlled trial to assess the efficacy of a single intramuscular dose of a vesicular stomatitis virus-based vaccine against Ebola virus disease (rVSV-ZEBOV) and 2) a single-arm phase II trial in front-line workers to determine the safety and activity of rVSV-ZEBOVProject ManagementHenao-Restrepo Ana MariaWHO
BIOSTEMI2016A randomized-controlled trial of a sirolimus-eluting stent with an ultrathin strut biodegradable polymer (Orsiro) versus an everolimus-eluting stent with a durable polymer (XIENCE PRIME) in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary interventionMethodology, Project, Management, Data Management, Monitoring, Statistics, ReportingProf. Dr. med. Pilgrim ThomasBiotronik AG
TOLERANT2015A randomized, controlled trial investigating the efficacy and safety of two different aflibercept treatment regimens (strict vs. relaxed) in patients with exudative age-related macular degeneration (AMD)Methodology, Project Management, Data Management, Monitoring, Statistics, ReportingProf. Dr. Dr. med. Wolf SebastianBayer (Schweiz) AG
DECO-SSI2015A randomized-controlled trial evaluating the effect preoperative Staphylococcus aureus decolonization on surgical site infections in patients undergoing elective orthopedic surgeryMethodology, Data Management, Monitoring, StatisticsDr. med. Brügger JanThe Lindenhof Fund for Teaching and Research, Bern
MDS Registry2014A multicenter observational, retro- and prospective, longitudinal study of patients with suspected or confirmed myelodysplastic syndrome (MDS), myelodysplastic/myeloproliferative neoplasia (MDS/MPN), or acute myeloidData ManagementDr. med. Bonadies NicolasNovartis Pharma Schweiz AGCelgene GmbH
Hämophilie-Register2015Das Schweizerische Hämophilie-Register soll eine hohe Datenqualität über Inzidenz von Hämophilie A und B sowie anderen schweren angeborenen Blutungskrankheiten, prophylaktischen und therapeutischen Einsatz von Gerinnungspräparaten und die Inzidenz der Hemmkörperentwicklung in der Schweiz sicherstellen.Data Management, StatisticsProf. Dr. med. Manuela AlbisettiSwiss Hemophilia Network (SHN)Universitäts-Kinderspital Zürich -Eleonorenstiftung
PACMAN2017Effects of the PCSK9 Antibody AliroCuMab on Coronary Atherosclerosis in PatieNts with Acute Myocardial Infarction. A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy And Optical Coherence Tomography Imaging StudyProject Management, Data Management, Statistics, Central Data Monitoring, On-site MonitoringProf. Dr. med. Lorenz Räber, Universitätsklinik für KardiologieSanofi / Regeneron
BEB2015A randomized phase II trial comparing BeEAM with BEAM as conditioning regimen for autologous stem cell transplantation (ASCT) in lymphoma patients (BEB-trial)MonitoringProf. Dr. med. Pabst ThomasEMPIRIS Mundipharma Medical Company
OPERAM2016A cluster-randomized trial evaluating whether structured drug review with appropriateness assessment (supported by a dedicated decision aid i.e. software) reduces the rate of drug-related hospital admissions in multimorbid patients with polypharmacy as compared to standard of careMethodology, Project Management, Data Management, Monitoring, Statistics, Clinical Investigation, Laboratory, ReportingProf. Dr. med. Nicolas RodondiEU HORIZON2020
MATRIX2015Minimising Adverse haemorrhagic events by TRansradial access site and systematic Implementation of angioX (MATRIX) TrialStatisticsProf. Dr. Marco ValgimigliMedicines Company Terumo
SWITCH2015Swiss trial of decompressive craniectomy versus best medical treatment of spontaneous supratentorial intracerebral hemorrhage (SWITCH): a randomized controlled trialData Management, Central Data Monitoring, Monitoring, StatisticsProf. Dr. med. Urs Fischer Prof. Dr. med. Jürgen BeckSNF Schweizerische Herzstiftung Inselspital
SENStrial2012A structured early palliative care intervention for patients with advanced cancer - a randomized controlled trial with a nested qualitative studyProject Management, Data Management, Monitoring, Statistics, Clinical Investigation, ReportingProf. Dr. med. Steffen EychmüllerSNF
BAG_HFV-Pilot2012A randomized-controlled trial with a method-comparison study nested in each arm to assess how accurately and consistently clinical trials are categorized using two different approaches: an approach using criteria set forth in the Swiss Human Research Act which was enacted after this trial or an intuitive, ad-hoc approachMethodology, Project Management Data Management, Statistics, ReportingBundesamt für Gesundheit BAG
CLEVER-ACS2019A phase II randomized double-blind multi-centre placebo-controlled trial on the effects of a short course of everolimus in patients with acute ST-Elevation Myocardial Infarction on infarct size, left ventricular remodelling and inflammationData Management, StatisticsProf. Dr. med. Frank RuschitzkaSNFNCT01529554
SAG TCCS2012A prospective Cohort study to determine the diagnostic performance and the clinical impact of a variety of tests, including conventional radiographs, computer tomographies (CT), serum tumour markers (AFP and beta-HCG) and clinical signs and symptoms aimed at early detection of relapse after curative therapy with documented complete remissionData Management, Statistics, Central Data Monitoring MonitoringDr. Christian Rothermundt Kantonsspital St. GallenSwisscancer Anna Lisa Stiftung Ostschweizer Stiftung für Klinische Krebsforschung OSKK
GCA Tocilizumab Rheumatology2013A phase II, randomized, double-blind, placebo controlled strudy of Tocilizumab in patients with Giant Cell ArteritisData Management, Monitoring, Statistics, ReportingProf. Dr. med. Peter M. VilligerRoche Pharma (Switzerland) Ltd
Bioscience Orsiro2013A Randomized Comparison of a Sirolimus-eluting Stent with a Biodegradable Polymer versus an Everolimus-eluting Stent with a Durable Polymer for Percutaneous Coronary RevascularizationMonitoringProf. Dr. Stephan WindeckerBIOTRONIK
Bioflow II2012Orsiro vs Xience stents with IVUS and OCT imaging substudiesStatisticsProf. Dr. Stephan WindeckerBIOTRONIK
PC Trial2012Randomized clinical trial comparing the efficacy of percutaneous closure of patent foramen ovale (PFO) with medical treatment in patients with cryptogenic embolismData Management StatisticsFoundation for Cardiovascular ResearchAbbott Cordis Medtronic
Global LEADERS2013Randomised trial to compare two dual-antiplatelet regimens in all-comers cardiovascular patientsMethodology, StatisticsEuropean Cardiovascular Research Institute (ECRI)Biosensors (Morges, Switzerland), AstraZeneca
SPIRIT (10.10.CLI)2012A randomized-controlled trial comparing enteral feeding using standard nutrition with a new formula (Nestlé) in ICU patientsMethodology, Data Management, Monitoring, Statistics, ReportingMaryam OlesenNestlé Healthscience
ETRELKA2012Effects of transcutaneous electrical stimulation (TENS) on knee pain and joint function in people with knee osteoarthritis: ETRELKAMethodology, Project Management, Data Management, Monitoring, Statistics, Clinical Investigation, ReportingPD Prof. Dr. med. Stephan ReichenbachARCO Foundation
Swiss TAVI Registry2011Patient Registry Cardiology: To assess the periprocedural, in hospital, 30 day, and one year clinical outcome of patients undergoing transcatheter aortic valve implantation (TAVI) in SwitzerlandData Management, Central Data Monitoring, StatisticsProf. Dr. Peter M. WenaweserEdwards Medtronic
HWI2012A randomized, double blind trial to compare symptomatic therapy of uncomplicated lower urinary tract infections to antibiotic treatment, both in the ambulatory settingMethodology, Project Management, Data Management, Monitoring, Statistics, Clinical Investigation, ReportingPD Dr. med. Andreas KronenbergSwiss National Foundation Swiss Academy of Medical Sciences SwissLife foundation Else Kroener-Fresenius foundation
Lichen2011Effectiveness of a topical progesterone therapy compared to conventional therapy with clobetasol propionate in patients with vulgar lichen sclerosus. A double-blind randomized phase II pilot studyMethodology, Project Management, Data Management, Monitoring, Statistics, ReportingProf. Dr. med. Andreas GünthertSNF
TTP Register2012An open ended registry of thrombotic thrombocytopenic purpuraMonitoring, StatisticsProf. Dr. med. Johanna A. Kremer HovingaSNF Mach-Gaensslen Foundation Baxter Innovations GmbH
COMFORTABLE-AMI2009A randomized-controlled trial comparing a stent eluting biolimus from an erodable coating with a bare-metal stent in patients with acute ST-elevation myocardial infarctionMethodology, Data Management, Monitoring, Statistics, ReportingProf. Dr. Stephan WindeckerSNF Biosensors
SWITCO65+2009A multicenter, interdisciplinary prospective cohort study to determine the predictors of clinically relevant medical outcomes, health-related quality of life, and costs of care among elderly patients with venous thromboembolismMethodology, Project Management, Data Management, Monitoring, Statistics, Laboratory, ReportingProf. Dr. med. Drahomir AujeskySNF
Titan-Endeavor RCT2007The study sought to compare the efficacy of passive stent coating with titanium-nitride-oxide (TiNO) with drug-eluting stents releasing zotarolimus (ZES)Methodology, Data Management, StatisticsProf. Dr. Stephan WindeckerInsel Foundation
LEADERS2006Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 5 year follow-up of a randomised non-inferiority trialStatisticsProf. Dr. Stephan WindeckerBiosensors Europe SA
HVI_Tanzania2012A randomized-controlled trial testing the effects of presumptive antihelminthic treatment on progression of HIV in antiretroviral-therapy-naïve HIV-positive patients in a rural African setting with presumed high prevalence of Helminth infectionsMethodology, Project Management, Statistics, ReportingProf. Dr. Christoph Hatz
TFA2009The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markersMethodology, Data Management, Statistics, Clinical InvestigationProf. Dr. med. Dr. hc Hugo SanerAgroscope
POC_OP2012A randomized-controlled trial to determine whether point-of-care coagulation testing of prothrombin time reduces the administration of fresh frozen plasma in patients undergoing major surgery and with intraoperative blood loss of more than 20% of their normal blood volumeData Management, StatisticsPD Dr. med. Natalie Urwyler