CTU Bern (Clinical Trials Unit)

Projects

Only major projects listed

CTUPP Nr. Name
Start year
End year
One-Sentence Summary
Involved workflows Sponsor Funding
0679
ELAN     An international, multicenter randomized-controlled trial comparing early versus standard initiation of anticoagulation in patients with stroke and atrial fibrillation. Data Management
Statistics
Monitoring
Prof. Dr. med. Urs Fischer SNF
0677
Simpl'HIV trial     Evaluation of a simplified strategy for the long-term management of HIV infection: a non-inferiority, randomized, controlled, open-label clinical trial. Data Management
Monitoring
Statistic
Prof. Dr. med. Alexandra Calmy SNF
0636
SERVE 2017   Effect of phosphodiesterase-5 inhibition with Tadalafil on SystEmic Right VEntricular function – a multi-center, double blind, randomized, placebo-controlled clinical trial – SERVE Trial. Methodology
Data Management
Monitoring
Statistics
Reporting
Prof. Dr. Markus Schwerzmann SNF
0628
SCOPE I 2017   A randomized controlled non-inferiority trial evaluating early safety and clinical efficacy of the Symetis ACURATE Neo compared to the Edwards Sapien 3 bioprosthesis in transcatheter aortic valve implantation. Data Management
Statistic
Monitoring
Reporting
Prof. Dr. Stephan Windecker Symetis SA
0689
H-PACS 2016   Prophylactic mesh implantation in patients requiring emergency laparotomy for the prevention of incisional hernia: A randomized controlled trial. Data Management
Monitoring
Statistic
Prof. Dr. med. Guido Beldi Lifecell
0670
DAWN2 CH 2016   Diabetes Attitudes Wishes and Needs (DAWN)2 Study in Switzerland: A survey study of psychosocial issues in diabetes and patient-centered diabetes care. Data Management
PD Dr. med. Markus Laimer Novo Nordisk AG
0640
NOSTONE 2016   A 3 year prospective, multicenter, double blind, placebo-controlled trial to assess the effectiveness of standard and low dose hydrochlorothiazide treatment in the recurrence prevention of calcium containing kidney stones. Methodology
Project Management
Data Management
Monitoring
Statistics
Prof. Dr. med. Daniel Fuster SNF
0634
MASTER DAPT 2016   Management of high bleeding risk patients post bioresorbable polymer STEnt implantation with an abbReviated versus prolonged DAPT regimen: an international, multicenter, randomized-controlled trial. Data Management
Monitoring
Statistic
Reporting
European Cardiovascular Research Institute (ECRI) Terumo Medical Corporation
0632
SYMPTOM NAVI Pilot 2016   Implementation of the Symptom Navi© Program for cancer patients in ambulatory services: A cluster-randomized pilot study. Data Management
Monitoring
Statistic
Dr. Manuela Eicher Stiftung Lindenhof Bern
0613
SCRIPT 2016   A randomized-controlled trial evaluating the effects of regulated cannabis selling in pharmacies - The Safer Cannabis - Research In Pharmacies Trial. Project Management
Data Management
Statistics
Dr. med. Sven Trelle University of Bern
0606
REVEAL in TAVI 2016   Prospective research project investigating the incidence of arrhythmias in patients undergoing transcatheter aortic valve implantation. Data Management Prof. Dr. med. Laurent Roten SNF
Medtronic (Schweiz) AG
0533
OPTICO BVS

2016

 

A randomized-controlled trial to compare optical-coherence-tomography- with angiography-guided percutaneous coronary intervention in patients with de-novo coronary artery disease undergoing coronary revascularization.

Methodology
Project Management
Data management
Monitoring
Statistics
Reporting

 

Dr. Räber Lorenz St. Jude Medical
0524
Effect of anaesthetic techniques on clinical outcome after LSP, RA vs GA, a prospective RCT 2016   A randomized-controlled trial to evaluate the effect of general versus regional anesthesia on clinical outcomes in patients undergoing lumbar spine surgery. Data Management
Statistics

 

MD Bänziger Bertram  
0415
OPERAM 2016   A cluster-randomized trial evaluating whether structured drug review with appropriateness assessment (supported by a dedicated decision aid i.e. software) reduces the rate of drug-related hospital admissions in multimorbid patients with polypharmacy as compared to standard of care. Methodology
Project Management
Data management
Monitoring
Statistics
Clinical investigation
Laboratory
Reporting

 

Prof. Dr. med. Nicolas Rodondi EU HORIZON2020
0458
BIOSTEMI
2016   A randomized-controlled trial of a sirolimus-eluting stent with an ultrathin strut biodegradable polymer (Orsiro) versus an everolimus-eluting stent with a durable polymer (XIENCE PRIME) in patients with acute ST‐segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Methodology
Project
Management
Data management
Monitoring
Statistics
Reporting
Prof. Dr. med. Pilgrim Thomas Biotronik AG
0536
SAAL 2015   CD34+  selected versus unselected  autologous stem cell transplantation in advanced stage mantle cell and diffuse large B-cell  lymphoma patients, a randomized phase II study (the SAAL-trial). Data Management
Monitoring
Statistics

 

Prof. Pabst Thomas  

Miltenyi Biotec GmbH

0468
OSCAR GALILEO 2015   A global multicenter, open-label, randomized, event-driven, active-controlled study comparing a rivaroxaban-based antithrombotic strategy to an antiplatelet-based strategy after transcatheter aortic valve replacement (TAVR) to optimize clinical outcomes. Monitoring Cardialysis BV Bayer AG
0465
Ebola vaccine trial 2015   Two trials of a new Ebola Virus vaccine: 1) ring-vaccination (cluster-) randomized-controlled trial to assess the efficacy of a single intramuscular dose of a vesicular stomatitis virus-based vaccine against Ebola virus disease (rVSV-ZEBOV) and 2) a single-arm phase II trial in front-line workers to determine the safety and activity of rVSV-ZEBOV. Project Management

Henao-Restrepo Ana Maria

 
0453
TOLERANT 2015  

A randomized, controlled trial investigating the efficacy and safety of two different aflibercept treatment regimens (strict vs. relaxed) in patients with exudative age-related macular degeneration (AMD).

Methodology
Project Management
Data management
Monitoring
Statistics
Reporting

 

Prof. Dr. Dr. med. Wolf Sebastian Bayer (Schweiz) AG
0449
DECO-SSI  2015   A randomized-controlled trial evaluating the effect preoperative Staphylococcus aureus decolonization on surgical site infections in patients undergoing elective orthopedic surgery. Methodology
Data management